Cardiac side population cells exhibit endothelial differentiation potential
نویسندگان
چکیده
منابع مشابه
CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation.
Heart failure remains a leading cause of morbidity and mortality. The cellular mechanism underlying the development of cardiac dysfunction is a decrease in the number of viable cardiomyocytes. Recent observations have suggested that the adult heart may contain a progenitor cell population. Side population (SP) cells, characterized by a distinct Hoechst dye efflux pattern, have been shown to exi...
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The heart has a limited ability to regenerate. It is important to identify therapeutic strategies that enhance cardiac regeneration in order to replace cardiomyocytes lost during the progression of heart failure. Cardiac progenitor cells are interesting targets for new regenerative therapies because they are self-renewing, multipotent cells located in the heart. Cardiac side population cells (c...
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The recent identification of progenitor populations that contribute to the developing heart in a distinct spatial and temporal manner has fundamentally improved our understanding of cardiac development. However, the mechanisms that direct atrial versus ventricular specification remain largely unknown. Here we report the identification of a progenitor population that gives rise primarily to card...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2007
ISSN: 2092-6413
DOI: 10.1038/emm.2007.71